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Target
DNA polymerase iota
Ligand
BDBM50276936
Substrate
n/a
Meas. Tech.
ChEMBL_541757 (CHEMBL1023119)
IC50
32500±n/a nM
Citation
 Kimura, T; Takeuchi, T; Kumamoto-Yonezawa, Y; Ohashi, E; Ohmori, H; Masutani, C; Hanaoka, F; Sugawara, F; Yoshida, H; Mizushina, Y Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorg Med Chem 17:1811-6 (2009) [PubMed]  Article 
Target
Name:
DNA polymerase iota
Synonyms:
POLI_MOUSE | Poli | Rad30b
Type:
PROTEIN
Mol. Mass.:
79658.67
Organism:
Mus musculus
Description:
ChEMBL_811415
Residue:
717
Sequence:
MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR
  
Inhibitor
Name:
BDBM50276936
Synonyms:
4-(3-hydroxybutanoyl)-2-[(1E,3E)-5-hydroxyhexa-1,3-dien-1-yl]-5-methoxy-2-methylfuran-3(2H)-one | CHEMBL513800
Type:
Small organic molecule
Emp. Form.:
C16H22O6
Mol. Mass.:
310.3423
SMILES:
COC1=C(C(=O)CC(C)O)C(=O)C(C)(O1)\C=C\C=C\C(C)O |c:2|
Structure:
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