Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50277852
Substrate
n/a
Meas. Tech.
ChEMBL_501421 (CHEMBL994680)
IC50
13±n/a nM
Citation
Humphries, PS; Benbow, JW; Bonin, PD; Boyer, D; Doran, SD; Frisbie, RK; Piotrowski, DW; Balan, G; Bechle, BM; Conn, EL; Dirico, KJ; Oliver, RM; Soeller, WC; Southers, JA; Yang, X Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists. Bioorg Med Chem Lett 19:2400-3 (2009) [PubMed] Article
More Info.:
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Inhibitor
Name:
BDBM50277852
Synonyms:
(3R,4R)-3-(3,4-dichlorophenyl)-2-((S)-2-methylbutyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid | CHEMBL483545
Type:
Small organic molecule
Emp. Form.:
C21H21Cl2NO3
Mol. Mass.:
406.302
SMILES:
CC[C@H](C)CN1[C@H]([C@H](C(O)=O)c2ccccc2C1=O)c1ccc(Cl)c(Cl)c1 |r|