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Target
Neuronal acetylcholine receptor subunit alpha-10
Ligand
BDBM50287815
Substrate
n/a
Meas. Tech.
ChEBML_143222
Ki
3333±n/a nM
Citation
 Elliott, RL; Kopecka, H; Gunn, DE; Lin, NH; Garvey, DS; Ryther, KB; Holladay, MW; Anderson, DJ; Campbell, JE; Sullivan, JP; Buckley, MJ; Gunther, KL; O'Neill, AB; Decker, MW; Arnerić, SP 2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands Bioorg Med Chem Lett 6:2283-2288 (1996)    Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-10
Synonyms:
ACH10_RAT | Chrna10 | Neuronal acetylcholine receptor protein alpha-10 subunit | Nicotinic acetylcholine receptor alpha9/alpha10
Type:
PROTEIN
Mol. Mass.:
49830.54
Organism:
Rattus norvegicus
Description:
ChEMBL_143222
Residue:
447
Sequence:
MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQAL
  
Inhibitor
Name:
BDBM50287815
Synonyms:
1-[2-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-phenyl]-ethanone | CHEMBL73275
Type:
Small organic molecule
Emp. Form.:
C14H19NO2
Mol. Mass.:
233.3062
SMILES:
CN1CCC[C@H]1COc1ccccc1C(C)=O
Structure:
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