Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-10
Ligand
BDBM50287823
Substrate
n/a
Meas. Tech.
ChEBML_143222
Ki
6889±n/a nM
Citation
 Elliott, RL; Kopecka, H; Gunn, DE; Lin, NH; Garvey, DS; Ryther, KB; Holladay, MW; Anderson, DJ; Campbell, JE; Sullivan, JP; Buckley, MJ; Gunther, KL; O'Neill, AB; Decker, MW; Arnerić, SP 2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands Bioorg Med Chem Lett 6:2283-2288 (1996)    Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-10
Synonyms:
ACH10_RAT | Chrna10 | Neuronal acetylcholine receptor protein alpha-10 subunit | Nicotinic acetylcholine receptor alpha9/alpha10
Type:
PROTEIN
Mol. Mass.:
49830.54
Organism:
Rattus norvegicus
Description:
ChEMBL_143222
Residue:
447
Sequence:
MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQAL
  
Inhibitor
Name:
BDBM50287823
Synonyms:
(S)-2-(Naphthalen-2-yloxymethyl)-pyrrolidine | CHEMBL541458
Type:
Small organic molecule
Emp. Form.:
C15H17NO
Mol. Mass.:
227.3016
SMILES:
C(Oc1ccc2ccccc2c1)[C@@H]1CCCN1
Structure:
Search PDB for entries with ligand similarity: