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Target
Dihydrofolate reductase
Ligand
BDBM50288821
Substrate
n/a
Meas. Tech.
ChEBML_54278
Ki
0.120±n/a nM
Citation
Gossett, LS; Habeck, LL; Gates, SB; Andis, SL; Worzalla, JF; Schultz, RM; Mendelsonn, LG; Kohler, W; Ratnam, M; Grindey, GB; Shih, C Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure Bioorg Med Chem Lett 6:473-476 (1996) Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND