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Target
Protein arginine N-methyltransferase 3 [N508S]
Ligand
BDBM50301077
Substrate
n/a
Meas. Tech.
ChEMBL_598372 (CHEMBL1037276)
IC50
>25000±n/a nM
Citation
 Wan, H; Huynh, T; Pang, S; Geng, J; Vaccaro, W; Poss, MA; Trainor, GL; Lorenzi, MV; Gottardis, M; Jayaraman, L; Purandare, AV Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies. Bioorg Med Chem Lett 19:5063-6 (2009) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3 [N508S]
Synonyms:
ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3)
Type:
Protein
Mol. Mass.:
59859.85
Organism:
Homo sapiens (Human)
Description:
O60678[N508S]
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50301077
Synonyms:
2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]imidazol-5-yl)piperidin-1-yl)-N-methylethanamine | CHEMBL584335
Type:
Small organic molecule
Emp. Form.:
C24H32N4O2
Mol. Mass.:
408.5365
SMILES:
CNCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(OC)cccc1OC
Structure:
Search PDB for entries with ligand similarity: