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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50301869
Substrate
n/a
Meas. Tech.
ChEMBL_598451 (CHEMBL1044410)
IC50
79±n/a nM
Citation
 Shen, HC; Ding, FX; Deng, Q; Xu, S; Tong, X; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Roy, S; Zhang, B; Tata, JR; Berger, JP; Colletti, SL A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 19:5716-21 (2009) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Ephx2 | Epoxide hydrolase 2 | HYES_RAT
Type:
PROTEIN
Mol. Mass.:
62337.15
Organism:
Rattus norvegicus
Description:
ChEMBL_1465995
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITFSQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTCIVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYVTVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALGRKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKWLKTEIQNPSVTSKI
  
Inhibitor
Name:
BDBM50301869
Synonyms:
7-(2-(trifluoromethyl)phenyl)-N-(4-(trifluoromethyl)phenyl)benzo[d]isoxazol-3-amine | CHEMBL578548
Type:
Small organic molecule
Emp. Form.:
C21H12F6N2O
Mol. Mass.:
422.3232
SMILES:
FC(F)(F)c1ccc(Nc2noc3c(cccc23)-c2ccccc2C(F)(F)F)cc1
Structure:
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