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Target
ATP-dependent 6-phosphofructokinase, muscle type
Ligand
BDBM50303854
Substrate
n/a
Meas. Tech.
ChEMBL_595165 (CHEMBL1037330)
EC50
>100000±n/a nM
Citation
 Dang, Q; Kasibhatla, SR; Xiao, W; Liu, Y; Dare, J; Taplin, F; Reddy, KR; Scarlato, GR; Gibson, T; van Poelje, PD; Potter, SC; Erion, MD Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. J Med Chem 53:441-51 (2010) [PubMed]  Article 
Target
Name:
ATP-dependent 6-phosphofructokinase, muscle type
Synonyms:
PFKAM_HUMAN | PFKM | PFKX | Phosphofructokinase muscle type
Type:
PROTEIN
Mol. Mass.:
85195.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_595165
Residue:
780
Sequence:
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
  
Inhibitor
Name:
BDBM50303854
Synonyms:
5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]imidazol-2-yl)furan-2-ylphosphonic acid | CHEMBL570790
Type:
Small organic molecule
Emp. Form.:
C17H21FN3O4P
Mol. Mass.:
381.3385
SMILES:
CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12
Structure:
Search PDB for entries with ligand similarity: