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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM28800
Substrate
n/a
Meas. Tech.
ChEMBL_627237 (CHEMBL1110806)
IC50
260±n/a nM
Citation
 Li, J; Kennedy, LJ; Shi, Y; Tao, S; Ye, XY; Chen, SY; Wang, Y; Hernández, AS; Wang, W; Devasthale, PV; Chen, S; Lai, Z; Zhang, H; Wu, S; Smirk, RA; Bolton, SA; Ryono, DE; Zhang, H; Lim, NK; Chen, BC; Locke, KT; O'Malley, KM; Zhang, L; Srivastava, RA; Miao, B; Meyers, DS; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Harrity, T; Kunselman, LK; Cap, M; Kadiyala, P; Hosagrahara, V; Zhang, L; Xu, C; Li, YX; Muckelbauer, JK; Chang, C; An, Y; Krystek, SR; Blanar, MA; Zahler, R; Mukherjee, R; Cheng, PT; Tino, JA Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem 53:2854-64 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM28800
Synonyms:
2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}phenyl)methyl](methoxycarbonyl)amino}acetic acid | BMS-687453
Type:
Small organic molecule
Emp. Form.:
C22H21ClN2O6
Mol. Mass.:
444.865
SMILES:
COC(=O)N(CC(O)=O)Cc1cccc(OCc2nc(oc2C)-c2ccc(Cl)cc2)c1
Structure:
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