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Target
Alpha-galactosidase A
Ligand
BDBM50241865
Substrate
n/a
Meas. Tech.
ChEMBL_639188 (CHEMBL1168041)
IC50
690±n/a nM
Citation
 Kato, A; Yamashita, Y; Nakagawa, S; Koike, Y; Adachi, I; Hollinshead, J; Nash, RJ; Ikeda, K; Asano, N 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem 18:3790-4 (2010) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
INN=Agalsidase | Melibiase | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | AGAL_HUMAN | GLA | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A)
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Human
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50241865
Synonyms:
2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine | CHEMBL469844
Type:
Small organic molecule
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.08
SMILES:
C([C@@H]1[C@H]([C@H]([C@H](N1)CO)O)O)O
Structure:
Search PDB for entries with ligand similarity: