Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 9
Ligand
BDBM50323166
Substrate
n/a
Meas. Tech.
ChEMBL_643844 (CHEMBL1211743)
Ki
5500±n/a nM
Citation
 Brigance, RP; Meng, W; Fura, A; Harrity, T; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes. Bioorg Med Chem Lett 20:4395-8 (2010) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 9
Synonyms:
DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9
Type:
Enzyme
Mol. Mass.:
98260.70
Organism:
Homo sapiens (Human)
Description:
Q86TI2
Residue:
863
Sequence:
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL
  
Inhibitor
Name:
BDBM50323166
Synonyms:
(5-(2,4-dichlorophenyl)-2-(3-methoxyphenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methanamine | CHEMBL1208844
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N4O
Mol. Mass.:
413.3
SMILES:
COc1cccc(c1)-c1cn2c(c(CN)c(C)nc2n1)-c1ccc(Cl)cc1Cl |(-10.78,-33.21,;-9.24,-33.19,;-8.48,-31.85,;-9.27,-30.51,;-8.51,-29.17,;-6.97,-29.16,;-6.19,-30.5,;-6.95,-31.83,;-4.65,-30.49,;-3.74,-31.73,;-2.27,-31.24,;-.94,-32,;.4,-31.23,;1.73,-32,;3.06,-31.22,;.39,-29.69,;1.72,-28.92,;-.95,-28.92,;-2.28,-29.7,;-3.75,-29.23,;-.93,-33.54,;-2.26,-34.31,;-2.26,-35.85,;-.93,-36.62,;-.93,-38.16,;.41,-35.85,;.41,-34.3,;1.74,-33.53,)|
Structure:
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