Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 8
Ligand
BDBM50323177
Substrate
n/a
Meas. Tech.
ChEMBL_643843 (CHEMBL1211742)
Ki
5500±n/a nM
Citation
 Brigance, RP; Meng, W; Fura, A; Harrity, T; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes. Bioorg Med Chem Lett 20:4395-8 (2010) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 8
Synonyms:
DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8
Type:
Enzyme
Mol. Mass.:
103342.62
Organism:
Homo sapiens (Human)
Description:
Q6V1X1
Residue:
898
Sequence:
MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
  
Inhibitor
Name:
BDBM50323177
Synonyms:
(7-(2,4-dichlorophenyl)-2-(4-methoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)methanamine | CHEMBL1209611
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N4O
Mol. Mass.:
413.3
SMILES:
COc1ccc(cc1)-c1cc2nc(C)c(CN)c(-c3ccc(Cl)cc3Cl)n2n1 |(-11.12,-26.33,;-10.34,-27.66,;-8.8,-27.64,;-8.04,-26.3,;-6.5,-26.29,;-5.73,-27.62,;-6.48,-28.96,;-8.01,-28.98,;-4.19,-27.61,;-3.29,-26.36,;-1.81,-26.83,;-.48,-26.05,;.86,-26.82,;2.19,-26.05,;.86,-28.36,;2.2,-29.13,;3.53,-28.35,;-.47,-29.13,;-.46,-30.67,;-1.79,-31.44,;-1.79,-32.98,;-.46,-33.75,;-.46,-35.29,;.88,-32.98,;.87,-31.43,;2.2,-30.65,;-1.8,-28.37,;-3.27,-28.86,)|
Structure:
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