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Target
Dual specificity protein phosphatase 1
Ligand
BDBM50326052
Substrate
n/a
Meas. Tech.
ChEMBL_655625 (CHEMBL1244669)
IC50
11500±n/a nM
Citation
 Molina, G; Vogt, A; Bakan, A; Dai, W; Queiroz de Oliveira, P; Znosko, W; Smithgall, TE; Bahar, I; Lazo, JS; Day, BW; Tsang, M Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol 5:680-7 (2009) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM50326052
Synonyms:
(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one | CHEMBL1241589
Type:
Small organic molecule
Emp. Form.:
C22H23NO
Mol. Mass.:
317.4241
SMILES:
O=C1\C(=C\c2ccccc2)C(NC2CCCCC2)c2ccccc12
Structure:
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