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Found 522 with Last Name = 'lazo' and Initial = 'js'
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50084504(CHEMBL3426991)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50096680((E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-...)
Affinity DataKi:  4.60E+3nMAssay Description:In vitro inhibitory activity against human recombinant Cdc25B phosphatase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50096693((E)-2-Naphthalen-2-yl-ethenesulfonic acid (4,5-dip...)
Affinity DataKi:  3.60E+4nMAssay Description:Inhibitory activity against human recombinant Cdc25B phosphatase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479538(CAS 381679-98-5 | CHEMBL490678)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479539(CAS 307545-04-6 | CHEMBL491275)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479540(CAS 329920-60-7 | CHEMBL452613)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479541(CAS 303796-42-1 | CHEMBL446965)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479542(CAS 31122-64-2 | CHEMBL491273)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479536(CHEMBL489096)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479535(CAS 160693-53-8 | CHEMBL491274)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50479537(CHEMBL504747)
Affinity DataKi: <5.00E+7nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  18nMAssay Description:The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  28.3nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  28.3nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM50535759(CHEMBL4471843)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336958(2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PKD2 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  50nMAssay Description:Inhibition of PTP4A1 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  52nMAssay Description:Inhibition of PTP4A2 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  53.2nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  58.7nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  58.8nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336961(3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...)
Affinity DataIC50:  74.9nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50267086(Adociaquinone B | CHEMBL476648)
Affinity DataIC50:  80nMAssay Description:Inhibition of histidine-tagged full length human Cdc25B expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  82.5nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  82.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  91.1nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  98.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  101nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571230(CHEMBL4862721)
Affinity DataIC50:  107nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50267086(Adociaquinone B | CHEMBL476648)
Affinity DataIC50:  110nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  114nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336958(2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336959(3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  132nMAssay Description:The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  142nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  163nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A1 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  193nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  193nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571225(CHEMBL4862502)
Affinity DataIC50:  206nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  227nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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