Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase D3
Ligand
BDBM50336962
Substrate
n/a
Meas. Tech.
In Vitro Radiometric Kinase Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
58.8±7.3 nM
Citation
 Lavalle, CR; Bravo-Altamirano, K; Giridhar, KV; Chen, J; Sharlow, E; Lazo, JS; Wipf, P; Wang, QJ Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol 10:5 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase D3
Synonyms:
EPK2 | KPCD3_HUMAN | PRKCN | PRKD3 | Protein kinase C nu | Protein kinase C nu type | Protein kinase C, PKC | Protein kinase C, PKC; classical/novel | Protein kinase EPK2 | Serine/threonine-protein kinase D3 (PKD3) | classical/novel | nPKC-nu
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100475.64
Organism:
Homo sapiens (Human)
Description:
gi_5031689
Residue:
890
Sequence:
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
  
Inhibitor
Name:
BDBM50336962
Synonyms:
2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]-1,5-thiazocin-6-one | CHEMBL1672573 | kb-NB165-92
Type:
Small organic molecule
Emp. Form.:
C12H11NO2S2
Mol. Mass.:
265.351
SMILES:
Oc1ccc2sc3c(SCCCNC3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: