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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50326439
Substrate
n/a
Meas. Tech.
ChEMBL_657899 (CHEMBL1248423)
IC50
40±n/a nM
Citation
 Akué-Gédu, R; Nauton, L; Théry, V; Bain, J; Cohen, P; Anizon, F; Moreau, P Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem 18:6865-73 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50326439
Synonyms:
CHEMBL1243128 | Methyl 3-formyl-1,10-dihydropyrrolo[2,3-a]carbazole-9-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H12N2O3
Mol. Mass.:
292.2888
SMILES:
COC(=O)c1cccc2c3ccc4c(C=O)c[nH]c4c3[nH]c12
Structure:
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