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Target
Mu-type opioid receptor
Ligand
BDBM50166066
Substrate
n/a
Meas. Tech.
ChEMBL_662961 (CHEMBL1250820)
Ki
135±n/a nM
Citation
 Giordano, C; Sansone, A; Masi, A; Lucente, G; Punzi, P; Mollica, A; Pinnen, F; Feliciani, F; Cacciatore, I; Davis, P; Lai, J; Ma, SW; Porreca, F; Hruby, V Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem 45:4594-600 (2010) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50166066
Synonyms:
CHEMBL362991 | H-Tyr-Pro-Phe-Pro-NH2 | MORPHICEPTIN | Tyr-Pro-Phe-Pro-NH2 | [D-Pro4]morphiceptin
Type:
Small organic molecule
Emp. Form.:
C28H35N5O5
Mol. Mass.:
521.608
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O |r|
Structure:
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