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Target
Phosphotransferase pUL97
Ligand
BDBM50330328
Substrate
n/a
Meas. Tech.
ChEMBL_681653 (CHEMBL1282584)
Ki
3±n/a nM
Citation
 Gentry, BG; Kamil, JP; Coen, DM; Zemlicka, J; Drach, JC Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother 54:3093-8 (2010) [PubMed]  Article 
Target
Name:
Phosphotransferase pUL97
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
76103.79
Organism:
Human cytomegalovirus
Description:
ChEMBL_681653
Residue:
688
Sequence:
MSSALRSRARSASLGTTTQGWDPPPLRRPSRARRRQWMREAAQAAAQAAVQAAQAAAAQVAQAHVDEDEVVDLMADEAGGGVTTLTTLSSVSTTTVLGHATFSACVRSDVMRDGEKEDAASDKENLRRPVVPSTSSRGSAASGDGYHGLRCRETSAMWSFEYDRDGDVTSVRRALFTGGSDPSDSVSGVRGGRKRPLRPPLVSLARTPLCRRRVGGVDAVLEENDVELRAESQDSAVASGPGRVPQPLSGSSGEESATAVEADSTSHDDVHCTCSNDQIITTSIRGLTCDPRMFLRLTHPELCELSISYLLVYVPKEDDFCHKICYAVDMSDESYRLGQGSFGEVWPLDRYRVVKVARKHSETVLTVWMSGLIRTRAAGEQQQPPSLMGTGVHRGLLTATGCCLLHNVTVHRRFHTDMFHHDQWKLACIDSYRRAFCTLADAIKFLNHQCRVCHFDITPMNVLIDVNPHNPSEIVRAALCDYSLSEPYPDYNERCVAVFQETGTARRIPNCSHRLRECYHPAFRPMPLQKLLICDPHARFPVAGLRRYCMSELSALGNVLGFCLMRLLDRRGLDEVRMGTEALLFKHAGAACRALENGKLTHCSDACLLILAAQMSYGACLLGEHGAALVSHTLRFVEAKMSSCRVRAFRRFYHECSQTMLHEYVRKNVERLLATSDGLYLYNAFRRT
  
Inhibitor
Name:
BDBM50330328
Synonyms:
(Z)-2-amino-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-1H-purin-6(9H)-one | (Z)-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-2-amino-1H-purin-6(9H)-one | 2-Amino-9-[2,2-bis-hydroxymethyl-cycloprop-(Z)-ylidenemethyl]-1,9-dihydro-purin-6-one | CHEMBL265948 | cyclopropavir
Type:
Small organic molecule
Emp. Form.:
C11H13N5O3
Mol. Mass.:
263.2526
SMILES:
Nc1nc2n(\C=C3\CC3(CO)CO)cnc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: