Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50337024
Substrate
n/a
Meas. Tech.
ChEMBL_718717 (CHEMBL1680936)
EC50
15±n/a nM
Citation
 Qin, J; Rao, A; Chen, X; Zhu, X; Liu, Z; Huang, X; Degrado, S; Huang, Y; Xiao, D; Aslanian, R; Cheewatrakoolpong, B; Zhang, H; Greenfeder, S; Farley, C; Cook, J; Kurowski, S; Li, Q; Heek, Mv; Chintala, M; Wang, G; Hsieh, Y; Li, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett 2:171-176 (2011) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
Gpr109 | Gpr109a | Gpr109b | HCAR2_MOUSE | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag
Type:
PROTEIN
Mol. Mass.:
41418.01
Organism:
Mus musculus
Description:
ChEMBL_820676
Residue:
360
Sequence:
MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
  
Inhibitor
Name:
BDBM50337024
Synonyms:
2-(difluoromethyl)-5-(3-(1-methylcyclopropyl)propyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1672639
Type:
Small organic molecule
Emp. Form.:
C15H16F2N2O3
Mol. Mass.:
310.2959
SMILES:
CC1(CCCc2cc(=O)oc3nc([nH]c(=O)c23)C(F)F)CC1
Structure:
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