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Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM62405
Substrate
n/a
Meas. Tech.
ChEMBL_749238 (CHEMBL1781181)
IC50
253±n/a nM
Citation
 Guerrero, M; Urbano, M; Velaparthi, S; Zhao, J; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett 21:3632-6 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM62405
Synonyms:
5-(2,5-dichlorophenyl)-N-(2-methyl-1-naphthalenyl)-2-furancarboxamide | 5-(2,5-dichlorophenyl)-N-(2-methyl-1-naphthyl)-2-furamide | 5-(2,5-dichlorophenyl)-N-(2-methylnaphthalen-1-yl)furan-2-carboxamide | 5-[2,5-bis(chloranyl)phenyl]-N-(2-methylnaphthalen-1-yl)furan-2-carboxamide | SR-02000000249 | SR-02000000249-1 | cid_44607574
Type:
Small organic molecule
Emp. Form.:
C22H15Cl2NO2
Mol. Mass.:
396.266
SMILES:
Cc1ccc2ccccc2c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
Structure:
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