Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50351992
Substrate
n/a
Meas. Tech.
ChEMBL_766140 (CHEMBL1826107)
Ki
9.08±n/a nM
Citation
 Abate, C; Hornick, JR; Spitzer, D; Hawkins, WG; Niso, M; Perrone, R; Berardi, F Fluorescent derivatives ofs receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells. J Med Chem 54:5858-67 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50351992
Synonyms:
CHEMBL1822599
Type:
Small organic molecule
Emp. Form.:
C41H60N4O3S
Mol. Mass.:
689.005
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCCOc1cccc2C(CCCN3CCN(CC3)C3CCCCC3)CCCc12
Structure:
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