Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50098668
Substrate
n/a
Meas. Tech.
ChEBML_38792
EC50
2000±n/a nM
Citation
 Beeley, L; Berge, J; Chapman, H; Dean, D; Kelly, J; Lowden, K; Kotecha, N; Morgan, H; Rami, H; Thompson, M; Vong, A; Ward, R A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor Bioorg Med Chem Lett 7:219-224 (1997)    Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50098668
Synonyms:
4-(3-tert-Butylamino-2-hydroxy-propoxy)-1,3-dihydro-benzoimidazol-2-one | CGP-12177A | CHEMBL36060
Type:
Small organic molecule
Emp. Form.:
C14H21N3O3
Mol. Mass.:
279.3348
SMILES:
CC(C)(C)NC[C@H](O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: