Reaction Details Report a problem with these data
Target
Protein phosphatase 1B
Ligand
BDBM50143518
Substrate
n/a
Meas. Tech.
ChEBML_161760
IC50
>100000±n/a nM
Citation
 Hart, ME; Chamberlin, AR; Walkom, C; Sakoff, JA; McCluskey, A Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. Bioorg Med Chem Lett 14:1969-73 (2004) [PubMed]  Article 
Target
Name:
Protein phosphatase 1B
Synonyms:
PP2C-beta | PP2CB | PPM1B | PPM1B_HUMAN | Protein phosphatase 1B | Protein phosphatase 2C beta | Protein phosphatase 2C isoform beta
Type:
PROTEIN
Mol. Mass.:
52620.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161756
Residue:
479
Sequence:
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
  
Inhibitor
Name:
BDBM50143518
Synonyms:
((1R,6R,7S)-3,5-Dioxo-4,10-dioxa-tricyclo[5.2.1.0*2,6*]dec-8-en-1-yl)-acetonitrile | CHEMBL176328
Type:
Small organic molecule
Emp. Form.:
C10H7NO4
Mol. Mass.:
205.1669
SMILES:
O=C1OC(=O)C2[C@@H]1[C@H]1O[C@]2(CC#N)C=C1 |c:15|
Structure:
Search PDB for entries with ligand similarity: