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Target
Kappa-type opioid receptor
Ligand
BDBM50066531
Substrate
n/a
Meas. Tech.
ChEMBL_145837 (CHEMBL755495)
Ki
95±n/a nM
Citation
 Husbands, SM; Sadd, J; Broadbear, JH; Woods, JH; Martin, J; Traynor, JR; Aceto, MD; Bowman, ER; Harris, LS; Lewis, JW 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. J Med Chem 41:3493-8 (1998) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42692.90
Organism:
Rattus norvegicus (rat)
Description:
P34975
Residue:
380
Sequence:
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
  
Inhibitor
Name:
BDBM50066531
Synonyms:
methyl 2-[17-[2-(4-chlorophenyl)-(E)-1-ethenylcarboxamido]-4-cyclopropylmethyl-14-oxo-(17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-10-yloxy]acetate
Type:
Small organic molecule
Emp. Form.:
C32H33ClN2O6
Mol. Mass.:
577.067
SMILES:
COC(=O)COc1ccc2CC3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35NC(=O)\C=C\c1ccc(Cl)cc1 |TLB:22:23:28:12.18.17,8:9:28:12.18.17|
Structure:
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