Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50074873
Substrate
n/a
Meas. Tech.
ChEMBL_201563 (CHEMBL804718)
IC50
9.4±n/a nM
Citation
 Nakazato, A; Ohta, K; Sekiguchi, Y; Okuyama, S; Chaki, S; Kawashima, Y; Hatayama, K Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs. J Med Chem 42:1076-87 (1999) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50074873
Synonyms:
CHEMBL542049 | {2-[4-Methoxy-3-(2-thiophen-2-yl-ethoxy)-phenyl]-ethyl}-dipropyl-amine; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C21H31NO2S
Mol. Mass.:
361.541
SMILES:
CCCN(CCC)CCc1ccc(OC)c(OCCc2cccs2)c1
Structure:
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