Reaction Details Report a problem with these data
Target
6-phosphogluconate dehydrogenase, decarboxylating
Ligand
BDBM50148767
Substrate
n/a
Meas. Tech.
ChEMBL_4337 (CHEMBL618442)
Ki
10±n/a nM
Citation
 Dardonville, C; Rinaldi, E; Barrett, MP; Brun, R; Gilbert, IH; Hanau, S Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. J Med Chem 47:3427-37 (2004) [PubMed]  Article 
Target
Name:
6-phosphogluconate dehydrogenase, decarboxylating
Synonyms:
6-phosphogluconate dehydrogenase | 6-phosphogluconate dehydrogenase (6PGD) | 6PGD_HUMAN | PGD | PGDH
Type:
Protein
Mol. Mass.:
53143.42
Organism:
Homo sapiens (Human)
Description:
P52209
Residue:
483
Sequence:
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA
  
Inhibitor
Name:
BDBM50148767
Synonyms:
2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate | 4-PHOSPHO-D-ERYTHRONOHYDROXAMIC ACID | CHEMBL116018 | Phosphoric acid mono-((1R,3R)-2,3-dihydroxy-3-hydroxycarbamoyl-propyl) ester
Type:
Small organic molecule
Emp. Form.:
C4H10NO8P
Mol. Mass.:
231.0979
SMILES:
ONC(=O)[C@H](O)[C@H](O)COP(O)(O)=O
Structure:
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