Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM10887
Substrate
n/a
Meas. Tech.
ChEMBL_306117 (CHEMBL830068)
IC50
1400±n/a nM
Citation
 Maryanoff, BE; McComsey, DF; Costanzo, MJ; Hochman, C; Smith-Swintosky, V; Shank, RP Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem 48:1941-7 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CAH2_RAT | Ca2 | Carbonate dehydratase II | Carbonic anhydrase II
Type:
PROTEIN
Mol. Mass.:
29119.00
Organism:
Rattus norvegicus
Description:
ChEMBL_306117
Residue:
260
Sequence:
MSHHWGYSKSNGPENWHKEFPIANGDRQSPVDIDTGTAQHDPSLQPLLICYDKVASKSIVNNGHSFNVEFDDSQDFAVLKEGPLSGSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQHPDGLAVLGIFLKIGPASQGLQKITEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGEAEELMVDNWRPAQPLKNRKIKASFK
  
Inhibitor
Name:
BDBM10887
Synonyms:
Sulfamate 7 | Topiramate (TPM) | US11535599, Example topiramate | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C12H21NO8S
Mol. Mass.:
339.362
SMILES:
CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r|
Structure:
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