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Target
DNA polymerase delta catalytic subunit
Ligand
BDBM50208251
Substrate
n/a
Meas. Tech.
ChEMBL_435942 (CHEMBL905347)
IC50
>1000000±n/a nM
Citation
 Kamisuki, S; Ishimaru, C; Onoda, K; Kuriyama, I; Ida, N; Sugawara, F; Yoshida, H; Mizushina, Y Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp. Bioorg Med Chem 15:3109-14 (2007) [PubMed]  Article 
Target
Name:
DNA polymerase delta catalytic subunit
Synonyms:
DNA polymerase (alpha/delta/epsilon) | DNA polymerase delta catalytic subunit | DNA polymerase delta subunit 1 | DNA polymerase subunit delta p125 | DPOD1_HUMAN | POLD | POLD1
Type:
PROTEIN
Mol. Mass.:
123636.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105737
Residue:
1107
Sequence:
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW
  
Inhibitor
Name:
BDBM50208251
Synonyms:
3-5-dimethyl-8-methoxy-3,4-dihydroisocoumarin | CHEMBL226463
Type:
Small organic molecule
Emp. Form.:
C12H14O3
Mol. Mass.:
206.2378
SMILES:
COc1ccc(C)c2CC(C)OC(=O)c12 |w:9.9|
Structure:
Search PDB for entries with ligand similarity: