Reaction Details Report a problem with these data
Target
DNA polymerase delta catalytic subunit
Ligand
BDBM50208246
Substrate
n/a
Meas. Tech.
ChEMBL_435942 (CHEMBL905347)
IC50
>1000000±n/a nM
Citation
 Kamisuki, S; Ishimaru, C; Onoda, K; Kuriyama, I; Ida, N; Sugawara, F; Yoshida, H; Mizushina, Y Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp. Bioorg Med Chem 15:3109-14 (2007) [PubMed]  Article 
Target
Name:
DNA polymerase delta catalytic subunit
Synonyms:
DNA polymerase (alpha/delta/epsilon) | DNA polymerase delta catalytic subunit | DNA polymerase delta subunit 1 | DNA polymerase subunit delta p125 | DPOD1_HUMAN | POLD | POLD1
Type:
PROTEIN
Mol. Mass.:
123636.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105737
Residue:
1107
Sequence:
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGRELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW
  
Inhibitor
Name:
BDBM50208246
Synonyms:
5-formyl-8-hydroxy-3-methyl-3,4-dihydroisocoumarin | CHEMBL226409
Type:
Small organic molecule
Emp. Form.:
C11H10O4
Mol. Mass.:
206.1947
SMILES:
CC1Cc2c(C=O)ccc(O)c2C(=O)O1 |w:1.0|
Structure:
Search PDB for entries with ligand similarity: