Reaction Details Report a problem with these data
Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50219766
Substrate
n/a
Meas. Tech.
ChEMBL_445899 (CHEMBL896189)
IC50
5.3±n/a nM
Citation
 Kitagawa, H; Ozawa, T; Takahata, S; Iida, M; Saito, J; Yamada, M Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK. J Med Chem 50:4710-20 (2007) [PubMed]  Article 
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
  
Inhibitor
Name:
BDBM50219766
Synonyms:
1-((4-(3-bromophenyl)-1H-imidazol-2-yl)methyl)-3-(5-(pyridin-2-ylthio)thiazol-2-yl)urea | 1-((5-(3-bromophenyl)-1H-imidazol-2-yl)methyl)-3-(5-(pyridin-2-ylthio)thiazol-2-yl)urea | CHEMBL390894
Type:
Small organic molecule
Emp. Form.:
C19H15BrN6OS2
Mol. Mass.:
487.396
SMILES:
Brc1cccc(c1)-c1c[nH]c(CNC(=O)Nc2ncc(Sc3ccccn3)s2)n1
Structure:
Search PDB for entries with ligand similarity: