Reaction Details Report a problem with these data
Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50223362
Substrate
n/a
Meas. Tech.
ChEMBL_450119 (CHEMBL900394)
IC50
1100±n/a nM
Citation
 Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem 15:7325-36 (2007) [PubMed]  Article 
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
  
Inhibitor
Name:
BDBM50223362
Synonyms:
CHEMBL237447 | N-benzothiazol-2-yl-2-[1-(3-nitro-phenyl)-meth-(E)-ylideneaminooxy]-acetamide
Type:
Small organic molecule
Emp. Form.:
C16H12N4O4S
Mol. Mass.:
356.356
SMILES:
[O-][N+](=O)c1cccc([CH+][N-]OCC(=O)Nc2nc3ccccc3s2)c1
Structure:
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