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Target
Trans-2-enoyl-ACP reductase II
Ligand
BDBM50216895
Substrate
n/a
Meas. Tech.
ChEMBL_456803 (CHEMBL923154)
IC50
760±n/a nM
Citation
 Kitagawa, H; Ozawa, T; Takahata, S; Iida, M Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK. Bioorg Med Chem Lett 17:4982-6 (2007) [PubMed]  Article 
Target
Name:
Trans-2-enoyl-ACP reductase II
Synonyms:
Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II
Type:
Enzyme
Mol. Mass.:
34170.89
Organism:
Streptococcus pneumoniae
Description:
n/a
Residue:
324
Sequence:
MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND
  
Inhibitor
Name:
BDBM50216895
Synonyms:
1-((1H-benzo[d]imidazol-2-yl)methyl)-3-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)urea | CHEMBL237837
Type:
Small organic molecule
Emp. Form.:
C17H15N5O3S2
Mol. Mass.:
401.463
SMILES:
CS(=O)(=O)c1ccc2nc(NC(=O)NCc3nc4ccccc4[nH]3)sc2c1
Structure:
Search PDB for entries with ligand similarity: