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Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50377863
Substrate
n/a
Meas. Tech.
ChEMBL_480083 (CHEMBL934808)
IC50
2600±n/a nM
Citation
 Graulich, A; Lamy, C; Alleva, L; Dilly, S; Chavatte, P; Wouters, J; Seutin, V; Liégeois, JF Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers. Bioorg Med Chem Lett 18:3440-5 (2008) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2 | KCNN2_HUMAN | SK2
Type:
PROTEIN
Mol. Mass.:
63788.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_480083
Residue:
579
Sequence:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50377863
Synonyms:
AG-525 | CHEMBL257156
Type:
Small organic molecule
Emp. Form.:
C27H38N2O4
Mol. Mass.:
454.6016
SMILES:
COc1cc2CCN(C)[C@@H](CCC[C@@H]3N(C)CCc4cc(OC)c(OC)cc34)c2cc1OC |r|
Structure:
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