Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50296967
Substrate
n/a
Meas. Tech.
ChEMBL_580942 (CHEMBL1054907)
EC50
>10000±n/a nM
Citation
Hattori, K; Orita, M; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Tanabe, D; Washizuka, K; Araki, T; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6. Bioorg Med Chem Lett 19:4679-83 (2009) [PubMed] Article
More Info.:
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Inhibitor
Name:
BDBM50296967
Synonyms:
3-(cyclohexyloxy)-4'-(2-((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-ylamino)ethyl)-N-(methylsulfonyl)biphenyl-4-carboxamide | CHEMBL557253
Type:
Small organic molecule
Emp. Form.:
C31H38N2O6S
Mol. Mass.:
566.708
SMILES:
C[C@H](NCCc1ccc(cc1)-c1ccc(C(=O)NS(C)(=O)=O)c(OC2CCCCC2)c1)[C@H](O)c1ccc(O)cc1 |r|