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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301125
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
1200±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301125
Synonyms:
(S)-2-((R)-2-((S)-2-cinnamamido-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL569695
Type:
Small organic molecule
Emp. Form.:
C30H37N9O4
Mol. Mass.:
587.6727
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccccc1)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(13.44,-24.45,;12.1,-23.69,;12.11,-22.15,;10.77,-24.45,;9.42,-23.7,;8.1,-24.47,;6.76,-23.7,;6.76,-22.16,;5.43,-21.39,;4.1,-22.16,;4.1,-23.7,;2.77,-21.38,;2.77,-19.84,;1.43,-19.08,;1.43,-17.54,;.1,-16.76,;-1.24,-17.54,;-1.24,-19.08,;.1,-19.84,;1.43,-22.15,;1.44,-23.69,;2.78,-24.46,;.11,-24.46,;-1.22,-23.69,;-2.55,-24.46,;-3.95,-23.83,;-4.99,-24.98,;-4.22,-26.31,;-2.72,-25.99,;.1,-26,;1.44,-26.76,;2.77,-25.99,;1.44,-28.3,;.11,-29.07,;.11,-30.61,;-1.24,-31.37,;-1.24,-32.91,;.1,-33.68,;1.44,-32.9,;1.43,-31.36,;8.1,-21.39,;9.42,-22.16,;8.1,-19.85,)|
Structure:
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