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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301128
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
3660±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301128
Synonyms:
(R)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(4-methoxyphenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL565927
Type:
Small organic molecule
Emp. Form.:
C31H39N9O5
Mol. Mass.:
617.6987
SMILES:
COc1ccc(C=CC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCN=C(N)N)C(N)=O)cc1 |r,w:7.7,wU:11.10,32.33,wD:21.21,(27.52,-11.06,;26.19,-10.29,;24.86,-11.06,;24.86,-12.6,;23.52,-13.37,;22.19,-12.59,;20.86,-13.36,;19.53,-12.59,;19.53,-11.05,;20.86,-10.28,;18.19,-10.29,;18.19,-8.75,;16.85,-7.98,;15.52,-8.75,;14.12,-8.12,;13.08,-9.27,;13.85,-10.59,;15.36,-10.28,;19.52,-7.98,;20.85,-8.75,;19.51,-6.44,;20.85,-5.67,;20.85,-4.13,;19.51,-3.36,;19.51,-1.82,;18.18,-1.05,;16.84,-1.82,;16.84,-3.36,;18.18,-4.13,;22.17,-6.44,;22.17,-7.98,;23.51,-5.67,;24.84,-6.44,;24.84,-7.98,;26.18,-8.75,;27.51,-7.98,;28.85,-8.74,;30.18,-7.97,;31.51,-8.74,;30.18,-6.43,;26.18,-5.67,;27.51,-6.44,;26.18,-4.13,;22.19,-11.07,;23.51,-10.29,)|
Structure:
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