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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301129
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
660±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301129
Synonyms:
(S)-2-((R)-2-((S)-2-(3-(3-chlorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL566162
Type:
Small organic molecule
Emp. Form.:
C30H36ClN9O4
Mol. Mass.:
622.118
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1cccc(Cl)c1)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(35.35,-6.6,;34.01,-5.84,;34.02,-4.29,;32.68,-6.61,;31.34,-5.84,;30.01,-6.61,;28.68,-5.84,;28.68,-4.3,;27.34,-3.53,;26.01,-4.3,;26.01,-5.84,;24.68,-3.53,;24.68,-1.99,;23.34,-1.22,;23.34,.32,;22.02,1.09,;20.68,.32,;20.68,-1.22,;22.02,-1.99,;23.35,-4.3,;23.35,-5.84,;24.69,-6.61,;22.02,-6.61,;20.69,-5.84,;19.35,-6.61,;17.95,-5.98,;16.92,-7.13,;17.69,-8.46,;19.2,-8.14,;22.01,-8.15,;23.35,-8.91,;24.68,-8.14,;23.35,-10.45,;22.02,-11.22,;22.02,-12.76,;20.68,-13.52,;20.68,-15.06,;22.01,-15.83,;23.35,-15.05,;24.68,-15.82,;23.34,-13.52,;30.01,-3.53,;31.35,-4.3,;30.01,-1.99,)|
Structure:
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