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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301132
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
1120±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301132
Synonyms:
(S)-5-guanidino-2-((R)-2-((S)-2-(3-(3-hydroxyphenyl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide | CHEMBL565740
Type:
Small organic molecule
Emp. Form.:
C30H39N9O5
Mol. Mass.:
605.688
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc(O)c1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(19.41,-46.1,;18.08,-45.33,;18.08,-43.79,;16.74,-46.1,;15.41,-45.34,;14.08,-46.11,;12.74,-45.34,;12.74,-43.8,;11.41,-43.03,;10.07,-43.79,;10.07,-45.33,;8.74,-43.02,;8.74,-41.48,;7.41,-40.71,;7.41,-39.17,;6.08,-38.4,;4.74,-39.17,;4.74,-40.71,;6.08,-41.48,;7.41,-43.79,;7.42,-45.33,;8.75,-46.1,;6.09,-46.1,;4.75,-45.33,;3.42,-46.1,;2.01,-45.47,;.98,-46.62,;1.75,-47.95,;3.26,-47.63,;6.08,-47.64,;7.41,-48.4,;8.75,-47.63,;7.41,-49.94,;6.08,-50.71,;6.08,-52.25,;4.74,-53.02,;4.74,-54.56,;6.07,-55.33,;7.41,-54.55,;8.75,-55.31,;7.41,-53.01,;14.08,-43.03,;15.41,-43.8,;14.08,-41.49,)|
Structure:
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