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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301136
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
1160±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301136
Synonyms:
(S)-5-guanidino-2-((R)-2-((S)-2-(3-(4-hydroxyphenyl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide | CHEMBL567039
Type:
Small organic molecule
Emp. Form.:
C30H39N9O5
Mol. Mass.:
605.688
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1ccc(O)cc1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(32.3,-28.05,;30.96,-27.29,;30.97,-25.74,;29.63,-28.05,;28.28,-27.3,;26.96,-28.06,;25.63,-27.3,;25.63,-25.76,;24.29,-24.98,;22.96,-25.75,;22.96,-27.29,;21.63,-24.98,;21.63,-23.44,;20.29,-22.67,;20.29,-21.13,;18.96,-20.36,;17.63,-21.13,;17.63,-22.67,;18.96,-23.44,;20.3,-25.75,;20.31,-27.29,;21.64,-28.06,;18.98,-28.06,;17.64,-27.29,;16.31,-28.06,;14.91,-27.43,;13.87,-28.57,;14.64,-29.9,;16.15,-29.59,;18.96,-29.6,;20.3,-30.36,;21.64,-29.58,;20.3,-31.9,;21.63,-32.66,;21.63,-34.2,;20.29,-34.96,;20.29,-36.49,;21.62,-37.25,;21.62,-38.79,;22.95,-36.48,;22.95,-34.95,;26.96,-24.98,;28.29,-25.76,;26.96,-23.44,)|
Structure:
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