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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301139
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
620±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301139
Synonyms:
CHEMBL566760 | N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-6-hydroxy-2-naphthamide
Type:
Small organic molecule
Emp. Form.:
C32H37N9O5
Mol. Mass.:
627.6935
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2cc(O)ccc2c1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(33.19,-5.01,;31.86,-4.24,;31.86,-2.69,;30.53,-5.01,;29.19,-4.24,;27.87,-5.02,;26.53,-4.24,;26.53,-2.7,;25.2,-1.93,;23.86,-2.7,;23.86,-4.24,;22.53,-1.93,;22.53,-.39,;21.19,.38,;21.19,1.92,;19.86,2.69,;18.53,1.92,;18.53,.38,;19.86,-.39,;21.19,-2.7,;21.2,-4.24,;22.54,-5.01,;19.87,-5.01,;18.53,-4.24,;17.2,-5.01,;15.8,-4.38,;14.77,-5.53,;15.53,-6.86,;17.04,-6.54,;19.86,-6.55,;21.2,-7.31,;22.53,-6.54,;21.2,-8.85,;19.86,-9.62,;19.86,-11.16,;21.2,-11.92,;21.21,-13.46,;22.54,-14.23,;22.55,-15.77,;23.88,-13.44,;23.87,-11.91,;22.53,-11.15,;22.53,-9.62,;27.87,-1.94,;29.19,-2.7,;27.87,-.4,)|
Structure:
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