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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301141
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
7280±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301141
Synonyms:
(S)-2-((R)-2-((S)-2-(3-(benzo[d][1,3]dioxol-4-yl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL570903
Type:
Small organic molecule
Emp. Form.:
C31H39N9O6
Mol. Mass.:
633.6981
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2OCOc12)C(N)=O |r,wU:22.30,7.7,wD:11.19,(32.56,-30.51,;31.22,-29.74,;31.23,-28.2,;29.89,-30.51,;28.55,-29.75,;27.22,-30.52,;25.89,-29.75,;25.89,-28.21,;24.55,-27.44,;23.22,-28.21,;23.22,-29.75,;21.89,-27.44,;21.89,-25.9,;20.55,-25.13,;20.55,-23.59,;19.22,-22.82,;17.89,-23.59,;17.89,-25.13,;19.22,-25.9,;20.55,-28.21,;20.56,-29.75,;21.9,-30.52,;19.23,-30.52,;17.9,-29.75,;16.56,-30.52,;15.16,-29.89,;14.13,-31.04,;14.9,-32.36,;16.4,-32.05,;19.22,-32.06,;20.56,-32.82,;21.89,-32.05,;20.56,-34.36,;19.22,-35.13,;19.22,-36.67,;20.55,-37.43,;20.56,-38.96,;19.22,-39.74,;17.88,-38.97,;16.41,-39.45,;15.51,-38.2,;16.41,-36.95,;17.88,-37.42,;27.22,-27.44,;28.55,-28.21,;27.22,-25.9,)|
Structure:
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