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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301144
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
3200±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301144
Synonyms:
(S)-2-((R)-2-((S)-2-(3-(1H-imidazol-4-yl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL565474
Type:
Small organic molecule
Emp. Form.:
C27H37N11O4
Mol. Mass.:
579.654
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cnc[nH]1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(33.71,-6.59,;32.38,-5.81,;32.38,-4.27,;31.05,-6.59,;29.71,-5.82,;28.39,-6.59,;27.05,-5.82,;27.05,-4.28,;25.72,-3.51,;24.38,-4.28,;24.38,-5.82,;23.05,-3.51,;23.05,-1.97,;21.71,-1.2,;21.71,.34,;20.38,1.11,;19.04,.34,;19.04,-1.2,;20.38,-1.97,;21.71,-4.27,;21.72,-5.81,;23.06,-6.59,;20.39,-6.59,;19.05,-5.81,;17.72,-6.59,;16.32,-5.95,;15.29,-7.11,;16.05,-8.44,;17.56,-8.12,;20.38,-8.13,;21.72,-8.89,;23.05,-8.12,;21.72,-10.43,;20.38,-11.2,;20.38,-12.74,;21.62,-13.63,;21.15,-15.1,;19.61,-15.1,;19.13,-13.63,;28.39,-3.51,;29.71,-4.28,;28.39,-1.97,)|
Structure:
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