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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301145
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
2790±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301145
Synonyms:
(S)-2-((R)-2-((S)-2-(2-fluoro-3-phenylacrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL569220
Type:
Small organic molecule
Emp. Form.:
C30H36FN9O4
Mol. Mass.:
605.6631
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C(F)=Cc1ccccc1)C(N)=O |r,w:34.36,wU:22.30,7.7,wD:11.19,(10.55,-27.38,;9.21,-26.62,;9.22,-25.08,;7.87,-27.38,;6.53,-26.63,;5.2,-27.4,;3.87,-26.63,;3.87,-25.09,;2.54,-24.32,;1.2,-25.09,;1.2,-26.63,;-.13,-24.32,;-.13,-22.78,;-1.47,-22.01,;-1.47,-20.47,;-2.79,-19.7,;-4.13,-20.47,;-4.13,-22.01,;-2.79,-22.78,;-1.46,-25.09,;-1.45,-26.63,;-.11,-27.39,;-2.78,-27.39,;-4.12,-26.63,;-5.45,-27.39,;-6.85,-26.76,;-7.88,-27.92,;-7.12,-29.25,;-5.61,-28.92,;-2.8,-28.93,;-1.45,-29.69,;-.12,-28.92,;-1.45,-31.23,;-.13,-31.99,;-2.79,-32,;-2.79,-33.54,;-4.13,-34.3,;-4.13,-35.84,;-2.8,-36.61,;-1.46,-35.83,;-1.46,-34.3,;5.2,-24.32,;6.53,-25.09,;5.2,-22.78,)|
Structure:
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