Reaction Details Report a problem with these data
Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50301148
Substrate
n/a
Meas. Tech.
ChEMBL_598563 (CHEMBL1043555)
EC50
990±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50301148
Synonyms:
(S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(4-phenylbut-3-enamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL565688
Type:
Small organic molecule
Emp. Form.:
C31H39N9O4
Mol. Mass.:
601.6993
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C\C=C\c1ccccc1)C(N)=O |r,wU:22.30,7.7,wD:11.19,(10.27,-4.36,;8.93,-3.61,;8.94,-2.07,;7.59,-4.37,;6.25,-3.62,;4.93,-4.38,;3.59,-3.62,;3.59,-2.08,;2.26,-1.31,;.92,-2.07,;.92,-3.61,;-.41,-1.3,;-.41,.24,;-1.74,1.01,;-1.74,2.55,;-3.07,3.32,;-4.41,2.55,;-4.41,1.01,;-3.07,.24,;-1.74,-2.07,;-1.73,-3.61,;-.39,-4.38,;-3.06,-4.38,;-4.4,-3.61,;-5.73,-4.38,;-7.13,-3.75,;-8.16,-4.9,;-7.4,-6.23,;-5.89,-5.91,;-3.07,-5.92,;-1.73,-6.67,;-.4,-5.91,;-1.73,-8.21,;-3.07,-8.99,;-3.07,-10.53,;-4.4,-11.29,;-5.73,-10.52,;-7.06,-11.29,;-7.06,-12.83,;-5.72,-13.6,;-4.4,-12.82,;4.93,-1.31,;6.25,-2.08,;4.93,.23,)|
Structure:
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