Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50301135
Substrate
n/a
Meas. Tech.
ChEMBL_598564 (CHEMBL1043556)
EC50
20500±n/a nM
Citation
 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett 19:5176-81 (2009) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R_MOUSE | Mc3r
Type:
PROTEIN
Mol. Mass.:
35808.24
Organism:
Mus musculus
Description:
ChEMBL_1498848
Residue:
323
Sequence:
MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
  
Inhibitor
Name:
BDBM50301135
Synonyms:
(S)-5-guanidino-2-((R)-2-((S)-2-(3-(4-hydroxyphenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide | CHEMBL569697
Type:
Small organic molecule
Emp. Form.:
C30H37N9O5
Mol. Mass.:
603.6721
SMILES:
NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(O)cc1)C(N)=O |r,w:32.33,wU:22.30,7.7,wD:11.19,(10.53,-27.66,;9.19,-26.89,;9.2,-25.35,;7.86,-27.66,;6.51,-26.91,;5.19,-27.67,;3.85,-26.91,;3.85,-25.37,;2.52,-24.59,;1.19,-25.36,;1.19,-26.9,;-.14,-24.59,;-.14,-23.05,;-1.48,-22.28,;-1.48,-20.74,;-2.81,-19.97,;-4.14,-20.74,;-4.14,-22.28,;-2.81,-23.05,;-1.47,-25.36,;-1.46,-26.9,;-.13,-27.66,;-2.79,-27.66,;-4.13,-26.9,;-5.46,-27.66,;-6.86,-27.04,;-7.9,-28.18,;-7.13,-29.51,;-5.62,-29.2,;-2.81,-29.2,;-1.47,-29.97,;-.14,-29.19,;-1.47,-31.51,;-.14,-32.27,;-.14,-33.81,;-1.48,-34.56,;-1.48,-36.1,;-.15,-36.86,;-.15,-38.4,;1.18,-36.09,;1.18,-34.56,;5.19,-24.59,;6.52,-25.37,;5.19,-23.05,)|
Structure:
Search PDB for entries with ligand similarity: