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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50322043
Substrate
n/a
Meas. Tech.
ChEMBL_642463 (CHEMBL1175836)
IC50
10±n/a nM
Citation
 Tsukada, T; Kanno, O; Yamane, T; Tanaka, J; Yoshida, T; Okuno, A; Shiiki, T; Takahashi, M; Nishi, T Discovery of potent and orally active tricyclic-based FBPase inhibitors. Bioorg Med Chem 18:5346-51 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50322043
Synonyms:
(2S,2'S)-diethyl 2,2'-((5-(2-amino-5-isobutylthiazol-4-yl)furan-2-yl)phosphoryl)bis(azanediyl)dipropanoate | CHEMBL259771 | MB06322 | ethyl (2S)-2-[({5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}({[(2S)-1-ethoxy-1-oxopropan-2-yl]amino})phosphoryl)amino]propanoate
Type:
Small organic molecule
Emp. Form.:
C21H33N4O6PS
Mol. Mass.:
500.549
SMILES:
CCOC(=O)[C@H](C)NP(=O)(N[C@@H](C)C(=O)OCC)c1ccc(o1)-c1nc(N)sc1CC(C)C |r|
Structure:
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