Reaction Details Report a problem with these data
Target
Outer membrane protein MIP
Ligand
BDBM50335225
Substrate
n/a
Meas. Tech.
ChEMBL_701873 (CHEMBL1657165)
IC50
6000±n/a nM
Citation
Juli, C; Sippel, M; Jäger, J; Thiele, A; Weiwad, M; Schweimer, K; Rösch, P; Steinert, M; Sotriffer, CA; Holzgrabe, U Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein. J Med Chem 54:277-83 (2011) [PubMed] Article
More Info.:
Target
Name:
Outer membrane protein MIP
Synonyms:
MIP_LEGPN | Macrophage infectivity potentiator | PPIase | Peptidyl-prolyl cis-trans isomerase | Rotamase | mip
Type:
PROTEIN
Mol. Mass.:
24869.94
Organism:
Legionella pneumophila
Description:
ChEMBL_701873
Residue:
233
Sequence:
MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
Inhibitor
Name:
BDBM50335225
Synonyms:
(S)-1-Phenylmethanesulfonyl-piperidine-2-carboxylic acid 3-(3,4,5-trimethoxy-phenyl)-propyl ester | (S)-3-(3,4,5-Trimethoxyphenyl)propyl 1-(benzylsulfonyl)-piperidine-2-carboxylate | CHEMBL109278
Type:
Small organic molecule
Emp. Form.:
C25H33NO7S
Mol. Mass.:
491.597
SMILES:
COc1cc(CCCOC(=O)[C@@H]2CCCCN2S(=O)(=O)Cc2ccccc2)cc(OC)c1OC