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Target
Dipeptidyl peptidase 1
Ligand
BDBM123781
Substrate
n/a
Meas. Tech.
ChEMBL_762818 (CHEMBL1816175)
IC50
>30000±n/a nM
Citation
 Banno, Y; Miyamoto, Y; Sasaki, M; Oi, S; Asakawa, T; Kataoka, O; Takeuchi, K; Suzuki, N; Ikedo, K; Kosaka, T; Tsubotani, S; Tani, A; Funami, M; Tawada, M; Yamamoto, Y; Aertgeerts, K; Yano, J; Maezaki, H Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. Bioorg Med Chem 19:4953-70 (2011) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_BOVIN | CTSC
Type:
PROTEIN
Mol. Mass.:
51956.30
Organism:
Bos taurus
Description:
ChEMBL_762818
Residue:
463
Sequence:
MGPWSGSRLVALLLLVYGAGSVRGDTPANCTYPDLLGTWVFQVGSSGSQRDVNCSVMGPPEKKVVVHLKKLDTAYDDFGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGGKVTSYCHETMTGWVHDVLGRNRACFTGRKTGNTSENVNVNTARLAGLEETYSNRLYRYNHDFVKAINAIQKSWTAAPYMEYETLTLKEMIRRGGGHSRRIPRPKPAPITAEIQKKILHLPTSWDWRNVHGINFVTPVRNQGSCGSCYSFASMGMMEARIRILTNNTQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEDCFPYTGTDSPCRLKEGCFRYYSSEYHYVGGFYGGCNEALMKLELVHQGPMAVAFEVYDDFLHYRKGVYHHTGLRDPFNPFELTNHAVLLVGYGTDAASGLDYWIVKNSWGTSWGENGYFRIRRGTDECAIESIALAATPIPKL
  
Inhibitor
Name:
BDBM123781
Synonyms:
3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenylisoquinoline-6-carboxamide (21) | CHEMBL1812901
Type:
Small organic molecule
Emp. Form.:
C21H23N3O2
Mol. Mass.:
349.4262
SMILES:
CC(C)Cn1c(CN)c(-c2ccccc2)c2cc(ccc2c1=O)C(N)=O
Structure:
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