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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50380043
Substrate
n/a
Meas. Tech.
ChEMBL_810739 (CHEMBL2015972)
IC50
12±n/a nM
Citation
 Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett 22:2497-502 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Human
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50380043
Synonyms:
CHEMBL2012612
Type:
Small organic molecule
Emp. Form.:
C24H31N3O3S
Mol. Mass.:
441.586
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CCC2CCCC2)s1 |r,wU:7.10,wD:4.3,(43.94,-23.77,;42.4,-23.79,;41.65,-25.13,;41.61,-22.47,;40.07,-22.48,;39.28,-21.16,;37.74,-21.18,;36.99,-22.53,;37.78,-23.85,;39.31,-23.83,;35.46,-22.54,;34.68,-21.23,;33.14,-21.25,;32.39,-22.58,;33.17,-23.9,;34.71,-23.89,;30.85,-22.6,;30.07,-21.27,;30.1,-23.94,;28.56,-23.96,;27.64,-22.72,;26.18,-23.21,;26.19,-24.76,;24.85,-25.51,;23.53,-24.73,;22.3,-25.65,;20.82,-25.21,;19.94,-26.47,;20.87,-27.7,;22.32,-27.2,;27.66,-25.22,)|
Structure:
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