Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50384640
Substrate
n/a
Meas. Tech.
ChEMBL_820675 (CHEMBL2037946)
EC50
5±n/a nM
Citation
 Palani, A; Rao, AU; Chen, X; Huang, X; Su, J; Tang, H; Huang, Y; Qin, J; Xiao, D; Degrado, S; Sofolarides, M; Zhu, X; Liu, Z; McKittrick, B; Zhou, W; Aslanian, R; Greenlee, WJ; Senior, M; Cheewatrakoolpong, B; Zhang, H; Farley, C; Cook, J; Kurowski, S; Li, Q; van Heek, M; Wang, G; Hsieh, Y; Li, F; Greenfeder, S; Chintala, M Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett 3:63-68 (2012) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag
Type:
PROTEIN
Mol. Mass.:
41476.06
Organism:
Rattus norvegicus
Description:
ChEMBL_820675
Residue:
360
Sequence:
MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
  
Inhibitor
Name:
BDBM50384640
Synonyms:
CHEMBL2036954
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4
Mol. Mass.:
262.2613
SMILES:
O=c1cc(CCC2CCC2)c2c([nH]c(=O)[nH]c2=O)o1
Structure:
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